How to give your little one a double boost to their immunity, keeping them strong and less prone to illness!
In the modern era, simply providing general nutrition for your baby may not be enough. Modern mothers therefore need to look for ways to boost immunity effectively in a 'double-action' way, starting with the gut as the first line of defense. An innovative and widely accepted nutritional supplement is the combination of 2'-FL (2'-Fucosyllactose) and GOS (Galacto-oligosaccharides) , which acts like a double shield , helping your baby confidently face harmful germs [1].
Layer 1: Blocks pathogens using a 'smart lure' mechanism from 2'-FL.
The first line of defense in immunity is to prevent pathogens from entering the body. 2'-FL acts as a decoy , capable of mimicking the structure of the intestinal wall [2]. When pathogens or bacteria enter the body, they are tricked into attaching to 2'-FL molecules instead of the actual intestinal wall [3]. This mechanism helps block pathogens from entering the bloodstream and allows them to be expelled from the body through the excretory system, significantly reducing the risk of infection and inflammation [4].
Layer 2: Build a microbial fortress with the power of 'prebiotic fiber' from GOS.
Besides trapping pathogens, building a strong internal ecosystem is equally important. GOS is a high-quality prebiotic fiber that acts as 'food' for healthy gut bacteria (Probiotics) [1]. When the body receives GOS regularly , it helps stimulate the growth of a huge number of good bacteria, the Bifidobacteria group [5]. This army of microbes will help take over the space on the intestinal wall, create balance for the digestive system to work well, and produce substances that help inhibit the growth of pathogenic bacteria from within [6].
Double the protective power: Reduce the risk of respiratory infections.
A key highlight is the synergistic effect of 2'-FL and GOS , which clinical research has shown that children receiving 2'-FL along with the prebiotic GOS have a reduced risk of respiratory infections. The incidence of respiratory infections was only 4% in the group receiving 2'-FL and GOS compared to 12% in the group not receiving it, representing an absolute risk reduction of 8% and a relative risk reduction of approximately 67% [4,6].
It was also found that children in the group receiving this complementary nutrient had significantly lower rates of fever and antibiotic use [4]. This is because a healthy digestive system signals the immune cells throughout the body to work effectively ( Systemic Immunity ) [3,6].
summarize
A two-layer immunity boost by choosing fortified milk containing both 2'-FL and GOS is a way to lay a solid foundation for your baby's health [1,6]. When your child has a strong front-line defense and an internal boost, they will be ready to learn and grow to their full potential without worrying about frequent illnesses [4].
Wongwaree family
Kasemrad International Hospital, Rattanathibet
Dr. Siriporn
Wongwaree family
Pediatric Allergy Specialist
and immunity.
Kasemrad Hospital
International Rattanathibet
Wongwaree family
Kasemrad International Hospital, Rattanathibet
reference
1. Garrido D, Ruiz-Moyano S, Lemay DG, Sela DA, German JB, Mills DA. Comparative transcriptomics reveals key differences in the response to milk oligosaccharides of infant gut-associated bifidobacteria. Sci Rep. 2015;5:13517.
2. Erney RM, Malone WT, Skelding MB, Marcon AA, Kleman-Leyer KM, O'Ryan ML, et al. Variability of human milk neutral oligosaccharides in a diverse population. J Pediatr Gastroenterol Nutr. 2000;30(2):181–192.
3. Reverri EJ, Devitt AA, Kajzer JA, Baggs GE, Borschel MW. Review of the clinical evidence for the benefits of the human milk oligosaccharide 2′-fucosyllactose (2′-FL) in infant nutrition. Nutrients. 2018;10(9):1342.
4. Lewis ZT, Totten SM, Smilowitz JT, Popovic M, Parker E, Lemay DG, et al. The role of human milk oligosaccharides in infant health. J Pediatr. 2015;167(1):S42–S51.
5. Bode L. Human milk oligosaccharides: every baby needs a sugar mama. Glycobiology. 2012;22(9):1147–1162.
6. Salli K, Anglenius H, Hirvonen J, Hibberd AA, Ahonen I, Saarinen MT, et al. 2′-Fucosyllactose influences Bifidobacterium infantis–Caco-2 adhesion and expression of inflammatory genes. Sci Rep. 2019;9:11530.
