2'-FL, an intelligent prebiotic, is a key helper in building an immune system.
The foundation of good health is centered on internal balance, particularly in the digestive system, which is home to more than 70% of immune cells [1]. One of the key nutrients to support this system is 2'-FL (2'-Fucosyllactose) , a natural fiber that is most abundant in breast milk (HMOs) [2,3]. It acts as a 'smart prebiotic' to build and maintain a healthy army of good bacteria. Prebiotics act as food for probiotics, or good bacteria in the gut, to balance the environment in the large intestine and stimulate the growth of good bacteria, while also boosting immunity [4].
2'-FL: An essential nutrient for the army of good gut bacteria.
Our gut is a battleground between good bacteria (probiotics) and pathogenic bacteria. What makes 2'-FL stand out from other prebiotics is its 'selective utilization' property [5] . 2'-FL travels through the digestive tract without being digested in the stomach, but is directed to feed the healthy Bifidobacterium bacteria in the large intestine [1].
When good bacteria are properly supplied, they multiply and build a strong 'microbial army' that can take over the gut wall, preventing foreign pathogens from settling or growing. This dense population of healthy bacteria provides lasting protection from within the body. [4,6]
Healthy gut = Healthy immune system
summarize
Wongwaree family
Kasemrad International Hospital, Rattanathibet
Dr. Siriporn
Wongwaree family
Dr. Siriporn Wongwaree
Pediatric Allergy Specialist
and immunity.
Kasemrad Hospital
International Rattanathibet
Wongwaree family
Kasemrad International Hospital, Rattanathibet
reference
1. Reverri EJ, Devitt AA, Kajzer JA, Baggs GE, Borschel MW. Review of the clinical evidence for the benefits of the HMO 2′-fucosyllactose (2′-FL) in infant nutrition. Nutrients. 2018;10.
2. Garrido D, Ruiz-Moyano S, Lemay DG, Sela DA, German JB, Mills DA. Comparative transcriptomics reveals key differences in the response to milk oligosaccharides of infant gut-associated bifidobacteria. Sci Rep. 2015;5.
3. Erney RM, Malone WT, Skelding MB, Marcon AA, Kleman-Leyer KM, O'Ryan ML, et al. Variability of human milk neutral oligosaccharides in a diverse population. J Pediatr Gastroenterol Nutr. 2000;30.
4. Bode L. Human milk oligosaccharides: Every baby needs a sugar mama. Glycobiology. 2012;22.
5. Salli K, Anglenius H, Hirvonen J, Hibberd AA, Ahonen I, Saarinen MT, et al. 2′-Fucosyllactose influences Bifidobacterium infantis–Caco-2 adhesion and expression of inflammatory genes. Sci Rep. 2019;9.
6. Vandenplas Y, Berger B, Carnielli VP, Ksiazyk J, Lagström H, Sanchez Luna M, et al. Human milk oligosaccharides in infant formula: A critical review of the evidence. Nutr Metab Insights. 2018;11.
